A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles

Molecules. 2018 Mar 18;23(3):684. doi: 10.3390/molecules23030684.


A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes.

Keywords: PEG-400; nitrogen fused heterocycles; nucleophilic aromatic substitution.

MeSH terms

  • Green Chemistry Technology / methods*
  • Heterocyclic Compounds, Fused-Ring / chemical synthesis
  • Heterocyclic Compounds, Fused-Ring / chemistry*
  • Nitriles / chemistry
  • Nitrogen / chemistry*
  • Pyrazines / chemistry
  • Pyrimidines / chemistry


  • Heterocyclic Compounds, Fused-Ring
  • Nitriles
  • Pyrazines
  • Pyrimidines
  • pyrimidine
  • Nitrogen