Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 10 (3)

The Effect of Dietary Glycaemic Index on Glycaemia in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials


The Effect of Dietary Glycaemic Index on Glycaemia in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Omorogieva Ojo et al. Nutrients.


Background: The increasing prevalence of diabetes in the United Kingdom and worldwide calls for new approaches to its management, and diets with low glycaemic index have been proposed as a useful means for managing glucose response. However, there are conflicting reports and differences in the results of studies in terms of their effectiveness. Furthermore, the impact of low-glycaemic index diets and their long-term use in patients with type 2 diabetes remains unclear.

Objectives: The objective of this study was to conduct a systematic review and meta-analysis of the effect of low-glycaemic index diets in patients with type 2 diabetes.

Methods: Search methods: Randomised controlled studies were selected from a number of databases (EBSCOHost with links to Health Research databases, PubMed, and grey literature) based on the Population, Intervention, Comparator, Outcomes and Study designs (PICOS) framework. The search terms included synonyms and Medical Subject Headings (MeSH) and involved the use of Boolean operators (AND/OR) which allowed the combination of words and search terms.

Selection criteria: As per the selection criteria, the following types of articles were selected: studies on randomised controlled trials, with year of publication between 2008 and 2018, including patients with type 2 diabetes. Thus, studies involving patients with gestational and type 1 diabetes were excluded, as were observational studies. Nine articles which met the inclusion criteria were selected for the systematic review, whereas only six articles which met the criteria were included in the meta-analysis.

Data collection and analysis: Studies were evaluated for quality and risk of bias. In addition, heterogeneity, meta-analysis, and sensitivity tests of the extracted data were carried out using Review Manager 5.3 (Review Manager, 2014).

Results: The findings of the systematic review showed that the low-glycaemic index (low-GI) diet resulted in a significant improvement (<0.05) in glycated haemoglobin (HbA1c) in two studies: low-GI diet Δ = -0.5% (95% CI, -0.61% to -0.39%) vs. high-cereal fibre diet Δ = -0.18% (95% CI, -0.29% to -0.07%); and low-GI legume diet Δ = -0.5% (95%, -0.6% to -0.4%) vs. high-wheat fibre diet Δ = -0.3% (95% Cl, -0.4 to -0.2%). There was a slight improvement in one study (low glycaemic response = 6.5% (6.3-7.1) vs. control = 6.6% (6.3-7.0) and no significant difference (p > 0.05) in four studies compared with the control diet. Four studies showed improvements in fasting blood glucose in low-GI diets compared to higher-GI diets or control: low-GI diet = 150.8 ± 8.7 vs. higher-GI diet = 157.8 ± 10.4 mg/dL, mean ± SD p = 0.43; low-GI diet = 127.7 vs. high-cereal fibre diet = 136.8 mg/dL, p = 0.02; low-GI diet = 6.5 (5.6-8.4) vs. standard diabetic diet = 6.7 (6.1-7.5) mmol/L, median and interquartile range p > 0.05; and low-GI diet = 7.3 ± 0.3 vs. conventional carbohydrate exchange diet = 7.7 ± 0.4 mmol/L, mean ± SEM (Standard Error of Mean) p < 0.05. The results of the meta-analysis and sensitivity tests demonstrated significant differences (p < 0.001 and p < 0.001, respectively) between the low-GI diet and the higher-GI diet or control diet in relation to glycated haemoglobin. Differences between the low-GI diet and higher-GI diet or control were significant (p < 0.05) with respect to the fasting blood glucose following meta-analysis.

Conclusion: The low-GI diet is more effective in controlling glycated haemoglobin and fasting blood glucose compared with a higher-GI diet or control in patients with type 2 diabetes.

Keywords: fasting blood glucose; glycaemic index; glycated haemoglobin; meta-analysis; randomised controlled trials; systematic review; type 2 diabetes.

Conflict of interest statement

The authors declare no conflict of interest.


Figure 1
Figure 1
PRISMA flow chart showing the selection of articles.
Figure 2
Figure 2
A risk of bias summary.
Figure 3
Figure 3
A risk of bias graph.
Figure 4
Figure 4
A forest plot showing the effect of low-GI diet on glycated haemoglobin (%).
Figure 5
Figure 5
A forest plot showing the effect of low-GI diet on fasting blood glucose (mg/dL).

Similar articles

See all similar articles

Cited by 11 PubMed Central articles

See all "Cited by" articles


    1. Zghebi S.S., Steinke D.T., Carr M.J., Rutter M.K., Emsley R.A., Ashcroft D.M. Examining trends in type 2 diabetes incidence, prevalence and mortality in the UK between 2004 and 2014. Diabetes Obes. Metab. 2017;19:1537–1545. doi: 10.1111/dom.12964. - DOI - PubMed
    1. Sharma M., Nazareth I., Petersen I. Trends in incidence, prevalence and prescribing in type 2 diabetes mellitus between 2000 and 2013 in primary care: A retrospective cohort study. BMJ Open. 2016;6:e010210. doi: 10.1136/bmjopen-2015-010210. - DOI - PMC - PubMed
    1. Haynes-Maslow L., Leone L.A. Examining the relationship between the food environment and adult diabetes prevalence by county economic and racial composition: An ecological study. BMC Public Health. 2017;17:648 doi: 10.1186/s12889-017-4658-0. - DOI - PMC - PubMed
    1. Hill J. Management of diabetes in South Asian communities in the UK. Prim. Health Care. 2007;17:49–55. doi: 10.7748/phc2007. - DOI
    1. National Collaborating Centre for Chronic Conditions (NCCCC) Type 2 Diabetes: National Clinical Guideline for Management in Primary and Secondary Care (Update) Royal College of Physicians; London, UK: 2008. - PubMed

MeSH terms