Morphological Survey from Neurons to Circuits of the Mouse Retina

Methods Mol Biol. 2018;1753:3-25. doi: 10.1007/978-1-4939-7720-8_1.

Abstract

The mouse retina has a layered structure that is composed of five classes of neurons supported by Müller glial and pigment epithelial cells. Recent studies have made progress in the classification of bipolar and ganglion cells, and also in the wiring of rod-driven signaling, color coding, and directional selectivity. Molecular biological techniques, such as genetic manipulation, transcriptomics, and fluorescence imaging, have contributed a lot to these advancements. The mouse retina has consistently been an important experimental system for both basic and clinical neurosciences.

Keywords: Amacrine; Bipolar; Chemical synapse; Electron microscopy; Ganglion; Gap junction; Mouse; Müller glia; Retina; Rod and cone.

Publication types

  • Review

MeSH terms

  • Animals
  • Genomics / methods
  • Mice
  • Microscopy, Electron / methods
  • Nerve Net / cytology*
  • Nerve Net / physiology
  • Nerve Net / ultrastructure
  • Optical Imaging / methods
  • Retinal Neurons / cytology*
  • Retinal Neurons / physiology
  • Retinal Neurons / ultrastructure
  • Retinal Pigment Epithelium / cytology*
  • Retinal Pigment Epithelium / physiology
  • Retinal Pigment Epithelium / ultrastructure
  • Transcriptome / physiology