Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 31 (6), 637-642

Action and Function of Akkermansia Muciniphila in Microbiome Ecology, Health and Disease

Affiliations
Review

Action and Function of Akkermansia Muciniphila in Microbiome Ecology, Health and Disease

Noora Ottman et al. Best Pract Res Clin Gastroenterol.

Abstract

The discovery of Akkermansia muciniphila has opened new avenues for the use of this abundant intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is known to colonize the mucosal layer of the human intestine where it triggers both host metabolic and immune responses. A. muciniphila is particularly effective in increasing mucus thickness and increasing gut barrier function. As a result host metabolic markers ameliorate. The mechanism of host regulation is thought to involve the outer membrane composition, including the type IV pili of A. muciniphila, that directly signal to host immune receptors. At the same time the metabolic activity of A. muciniphila leads to the production of short chain fatty acids that are beneficial to the host and microbiota members. This contributes to host-microbiota and microbe-microbe syntrophy The mucolytic activity and metabolite production make A. muciniphila a key species in the mucus layer, stimulating beneficial mucosal microbial networks. This well studied member of the microbiota has been studied in three aspects that will be further described in this review: i) A. muciniphila characteristics and mucin adaptation, ii) its role as key species in the mucosal microbiome, and iii) its role in host health.

Keywords: Akkermansia muciniphila; Microbiome; Mucus; Pharmabiotic; Probiotic.

Similar articles

See all similar articles

Cited by 17 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback