Nanopharmaceuticals for wound healing - Lost in translation?

Adv Drug Deliv Rev. 2018 Apr;129:194-218. doi: 10.1016/j.addr.2018.03.005. Epub 2018 Mar 19.

Abstract

Today, many of the newly developed pharmaceuticals and medical devices take advantage of nanotechnology and with a rising incidence of chronic diseases such as diabetes and cardiovascular disease, the number of patients afflicted globally with non-healing wounds is growing. This has created a requirement for improved therapies and wound care. However, converting the strategies applied in early research into new products is still challenging. Many of them fail to comply with the market requirements. This review discusses the legal and scientific challenges in the design of nanomedicines for wound healing. Are they lost in translation or is there a new generation of therapeutics in the pipeline?

Keywords: Advanced wound healing therapies; Biomaterials; Current regulatory perspective; Nanomaterials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems
  • Drug Discovery
  • Humans
  • Nanomedicine*
  • Nanostructures / chemistry*
  • Nanotechnology*
  • Polymers / chemistry
  • Polymers / pharmacology*
  • Wound Healing / drug effects*

Substances

  • Polymers