Role of Hippo signaling in regulating immunity

Cell Mol Immunol. 2018 Dec;15(12):1003-1009. doi: 10.1038/s41423-018-0007-1. Epub 2018 Mar 22.

Abstract

The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In particular, patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome. MST1/2 kinases, the mammalian orthologs of Drosophila Hippo, may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity. In this review, we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals, T cell immunity, as well as the implications of Hippo signaling for tumor immunity.

Keywords: MST1/2; The Hippo pathway; adaptive immunity; innate immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Drosophila / immunology*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Humans
  • Immunity, Innate
  • Immunologic Deficiency Syndromes / immunology*
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction
  • T-Lymphocytes / immunology*

Substances

  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • STK4 protein, human
  • Protein-Serine-Threonine Kinases
  • hpo protein, Drosophila