Associations between atopic dermatitis and other disorders

F1000Res. 2018 Mar 12:7:303. doi: 10.12688/f1000research.12975.1. eCollection 2018.

Abstract

Atopic dermatitis is a heterogeneous, chronic, and inflammatory skin disease that is associated with a profound symptom burden. Recent studies have demonstrated associations between atopic dermatitis and a number of multi-organ and systemic disorders. The origin of these comorbid conditions is likely multifactorial, with combined effects of skin-barrier disruption, immune dysregulation, intense symptoms, and iatrogenic complications. Some of these comorbid conditions appear to be related to the underlying severity of atopic dermatitis and inadequate disease control. This review will summarize recent developments in the understanding of the comorbid health disorders associated with atopic dermatitis, particularly infections, sleep disturbances, and cardiovascular disease.

Keywords: atopic dermatitis; comorbidities; eczema.

Publication types

  • Review

Grants and funding

The author is supported by the Dermatology Foundation.