Tumour endoprosthesis replacement in the proximal tibia after intra-articular knee resection in patients with sarcoma and recurrent giant cell tumour

Int Orthop. 2018 Oct;42(10):2475-2481. doi: 10.1007/s00264-018-3893-z. Epub 2018 Mar 22.


Purpose: Proximal tibia replacements are commonly associated with post-operative complications and poor functional results due to an insufficiency of the extensor mechanism.

Methods: This study evaluated the clinical results with a special emphasis of the extensor mechanism reconstruction with a reattachment tube and complications after intra-articular resection of the proximal tibia and reconstruction with a tumour endoprosthesis (MUTARS®) in 98 patients (median age 18 years) with malignant bone tumours or giant cell tumours.

Results: Kaplan-Meier analysis showed that the limb survival rates were 94.9, 90.5 and 74.5% at one, two and ten years, respectively. Periprosthetic infection was the most common reason for secondary amputation (eight patients). The cumulative incidence rates of prosthetic failure (Henderson II-IV) were 18% at two years and 29% at five years post-operatively. An active extension deficit of more than 10° was noted in six patients only.

Conclusions: These results suggest that limb salvage with tumour prostheses after intra-articular resection can achieve good functional results with an active extension of the knee in the majority of patients. While mechanical complications can be treated successfully with revision surgery, periprosthetic infection continues to be the main reason for secondary amputation.

Keywords: Extensor mechanism; Megaprosthesis; Proximal tibia replacement; Reattachment tube; Sarcoma; Tumour prosthesis.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bone Neoplasms / surgery
  • Child
  • Female
  • Giant Cell Tumors / surgery*
  • Humans
  • Kaplan-Meier Estimate
  • Knee Joint / pathology
  • Knee Joint / surgery
  • Knee Prosthesis / adverse effects*
  • Limb Salvage / adverse effects
  • Male
  • Middle Aged
  • Orthopedic Procedures / adverse effects
  • Orthopedic Procedures / methods*
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / etiology
  • Postoperative Complications / surgery
  • Prosthesis Failure / etiology
  • Reoperation / adverse effects
  • Retrospective Studies
  • Sarcoma / surgery*
  • Tibia / surgery*
  • Treatment Outcome
  • Young Adult