Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity

Chem Biodivers. 2018 May;15(5):e1700560. doi: 10.1002/cbdv.201700560. Epub 2018 May 6.

Abstract

Three new compounds (1 - 3), including two euphane type triterpenes, 24,24-dimethoxy-25,26,27-trinoreuphan-3β-ol (1) and (24S)-24-hydroperoxyeupha-8,25-dien-3β-ol (2), and an ent-atisine diterpene, ent-atisane-3α,16α,17-triol (3), were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4 - 11). The structures of compounds (1 - 11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC50 = 1.38 μm).

Keywords: Euphorbia antiquorum; anti-HIV; diterpenes; triterpenes.

MeSH terms

  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification
  • Anti-HIV Agents / pharmacology*
  • Cell Line, Transformed
  • Cell Transformation, Viral / drug effects
  • Dose-Response Relationship, Drug
  • Euphorbia / chemistry*
  • HIV-1 / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Structure-Activity Relationship
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Terpenes

Associated data

  • GENBANK/AF324493.2