PROSPECTS OF C60 FULLERENE APPLICATION AS A MEAN OF PREVENTION AND CORRECTION OF ISCHEMIC-REPERFUSION INJURY IN THE SKELETAL MUSCLE TISSUE

Fiziol Zh (1994). 2016;62(3):66-77. doi: 10.15407/fz62.03.066.

Abstract

lack of accurate diagnostic tests for the rapid detection of ischemic injury remains an urgent problem. In this context, a search for specific markers of ischemia as well as new therapeutic agents for prevention and treatment of ischemic injury continues. Water-soluble nano-sized C60 fullerenes, as powerful antioxidants, can act as promising means for correction of various muscle system states, in the base of which lie the destructive effects of free radicals.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / therapeutic use*
  • Free Radicals / metabolism
  • Fullerenes / chemistry
  • Fullerenes / therapeutic use*
  • Humans
  • Muscle, Skeletal / blood supply
  • Muscle, Skeletal / drug effects*
  • Nanoparticles / chemistry*
  • Reperfusion Injury / metabolism
  • Reperfusion Injury / prevention & control*

Substances

  • Antioxidants
  • Free Radicals
  • Fullerenes
  • fullerene C60