Patient Enrichment for Precision-Based Cancer Clinical Trials: Using Prospective Cohort Surveillance as an Approach to Improve Clinical Trials

Clin Pharmacol Ther. 2018 Jul;104(1):23-26. doi: 10.1002/cpt.1051. Epub 2018 Mar 23.


Technological advances have led to the identification of biomarkers and development of novel target-based therapies. While some novel therapies have improved patient outcomes, the prevalence and diversity of biomarkers and targets in patient populations, especially patients with cancer, has created a challenge for the design and performance of clinical trials. To address this challenge we propose that prospective cohort surveillance of patients may be a solution to promote clinical trial matching for patients in need.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic*
  • Cohort Studies
  • Data Collection
  • Humans
  • Informed Consent
  • Molecular Targeted Therapy
  • Neoplasms / drug therapy*
  • Observational Studies as Topic
  • Patient Selection*
  • Precision Medicine*
  • Prospective Studies
  • Registries*