Modification of apparent intracerebral hematoma volume on T2 -weighted images during normobaric oxygen therapy may contribute to false diagnosis

J Clin Neurosci. 2018 Jun;52:105-108. doi: 10.1016/j.jocn.2018.01.046. Epub 2018 Mar 21.


It was previously reported that normobaric oxygen therapy (NBO) significantly affected T2-weighted imaging in a mouse model of intracerebral hemorrhage (ICH). However, it is unclear whether a similar phenomenon exists in large volume ICH as seen in human pathology. We investigated the effects of NBO on T2-weighted images in a pig model of ICH. Our data show that NBO makes disappear a peripheral crown of the hematoma, which in turn decreases the apparent volume of ICH by 18%. We hypothesized that this result could be translated to ICH in human, and subsequently could lead to inaccurate diagnostic.

Keywords: Diagnostic errors; Intracerebral hemorrhage; Magnetic resonance imaging; Oxygen inhalation therapy.

MeSH terms

  • Animals
  • Cerebral Hemorrhage / diagnostic imaging*
  • Diagnostic Errors
  • Hematoma / diagnostic imaging*
  • Magnetic Resonance Imaging / standards*
  • Oxygen Inhalation Therapy / adverse effects*
  • Swine