Evidence for the role of a siderophore in promoting Vibrio anguillarum infections

J Gen Microbiol. 1986 Oct;132(10):2949-52. doi: 10.1099/00221287-132-10-2949.

Abstract

Vibrio anguillarum strain 775 harbouring the virulence plasmid pJM1 produces a plasmid-mediated siderophore that can crossfeed siderophore-deficient, receptor-proficient mutants of V. anguillarum in vitro. Experimental infections of salmonid fishes with mixtures consisting of the wild-type strain and a siderophore-deficient, receptor-proficient mutant resulted in recovery of both the wild-type and the mutant strain, while in infections with mixtures consisting of the wild-type strain and a siderophore-deficient, receptor-deficient mutant only the wild-type strain could be recovered. These results suggest that the V. anguillarum plasmid-mediated siderophore is produced in vivo in a diffusible form and that it is an important factor of virulence.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Ionophores / metabolism*
  • Iron / metabolism
  • Iron Chelating Agents / metabolism*
  • Salmon
  • Siderophores
  • Trout
  • Vibrio / metabolism
  • Vibrio / pathogenicity*
  • Virulence

Substances

  • Ionophores
  • Iron Chelating Agents
  • Siderophores
  • Iron