PTTG-1 (Securin) immunoexpression in meningiomas correlates with tumor grade and proliferation rate: potential use as a diagnostic marker of malignancy

APMIS. 2018 Apr;126(4):295-302. doi: 10.1111/apm.12825.


This study essentially aims to contribute to the immunohistochemical investigation of the use of pituitary tumor transforming gene (PTTG) as a marker of cell proliferation or advanced tumor grade in meningiomas of various WHO grades. In all, 51 cases were recovered in total, 21 Grade-I, 23 Grade-II and 7 Grade-III meningiomas. Mitotic index (MI), Ki-67/MiB-1 positivity percentage and PTTG expression were analyzed in correlation to each other as well as to the tumor WHO grades. All three biomarkers showed a high diagnostic significance and a strong association with WHO grades. In comparison, PTTG expression was on a par with the other two indices, and performed very well regarding identification of advanced grade tumors. PTTG may be considered an important diagnostic tool and serve in the future as a novel prognosticator of the biological behavior of all grade meningiomas as well as a useful high-risk patient selection tool.

Keywords: Ki-67; Pituitary tumor transforming gene; WHO grade; meningioma; mitotic index.

MeSH terms

  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Ki-67 Antigen / genetics
  • Ki-67 Antigen / metabolism
  • Meningeal Neoplasms / diagnosis
  • Meningeal Neoplasms / metabolism*
  • Meningeal Neoplasms / pathology*
  • Meningeal Neoplasms / physiopathology
  • Meningioma / diagnosis
  • Meningioma / metabolism*
  • Meningioma / pathology*
  • Meningioma / physiopathology
  • Mitosis
  • Securin / genetics
  • Securin / metabolism*


  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Securin
  • pituitary tumor-transforming protein 1, human