A Proposed Circuit Computation in Basal Ganglia: History-Dependent Gain

Mov Disord. 2018 May;33(5):704-716. doi: 10.1002/mds.27321. Epub 2018 Mar 24.


In this Scientific Perspectives we first review the recent advances in our understanding of the functional architecture of basal ganglia circuits. Then we argue that these data can best be explained by a model in which basal ganglia act to control the gain of movement kinematics to shape performance based on prior experience, which we refer to as a history-dependent gain computation. Finally, we discuss how insights from the history-dependent gain model might translate from the bench to the bedside, primarily the implications for the design of adaptive deep brain stimulation. Thus, we explicate the key empirical and conceptual support for a normative, computational model with substantial explanatory power for the broad role of basal ganglia circuits in health and disease. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Keywords: basal ganglia; bradykinesia; dopamine; mouse models; neural circuits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basal Ganglia / physiology*
  • Biomechanical Phenomena
  • Computer Simulation*
  • Humans
  • Models, Neurological*
  • Movement / physiology
  • Neural Pathways / physiology*