Distribution of IFITM3 polymorphism (dbSNP: rs12252) in mestizo populations in four states of Mexico

Int J Immunogenet. 2018 Jun;45(3):146-151. doi: 10.1111/iji.12361. Epub 2018 Mar 25.

Abstract

Interferon-inducible transmembrane protein 3 (IFITM3) participates in the defense against viral infections. This study identified and compared the frequency of the IFITM3 rs12252 polymorphism in 410 individuals in western Mexico. The western Mexican allelic frequencies (frequency of the "C" allele = 0.18) differ from some American, East Asian and European populations.

Keywords: disease susceptibility; gene frequency; immunity; innate; interferon.

MeSH terms

  • Adolescent
  • Adult
  • Alleles*
  • Ethnicity / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Healthy Volunteers
  • Humans
  • Membrane Proteins / genetics*
  • Mexico
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • RNA-Binding Proteins / genetics*
  • Young Adult

Substances

  • IFITM3 protein, human
  • Membrane Proteins
  • RNA-Binding Proteins