Self-assembled, ellipsoidal polymeric nanoparticles for intracellular delivery of therapeutics

J Biomed Mater Res A. 2018 Jul;106(7):2048-2058. doi: 10.1002/jbm.a.36400. Epub 2018 Apr 30.

Abstract

Nanoparticle shape has emerged as a key regulator of nanoparticle transport across physiological barriers, intracellular uptake, and biodistribution. We report a facile approach to synthesize ellipsoidal nanoparticles through self-assembly of poly(glycerol sebacate)-co-poly(ethylene glycol) (PGS-co-PEG). The PGS-PEG nanoparticle system is highly tunable, and the semiaxis length of the nanoparticles can be modulated by changing PGS-PEG molar ratio and incorporating therapeutics. As both PGS and PEG are highly biocompatible, the PGS-co-PEG nanoparticles show high hemo-, immuno-, and cytocompatibility. Our data suggest that PGS-co-PEG nanoparticles have the potential for use in a wide range of biomedical applications including regenerative medicine, stem cell engineering, immune modulation, and cancer therapeutics. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2048-2058, 2018.

Keywords: bovine serum albumin; drug delivery; shape-specific nanoparticles; therapeutic delivery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Decanoates / chemical synthesis
  • Decanoates / chemistry*
  • Drug Delivery Systems / methods*
  • Endocytosis
  • Glycerol / analogs & derivatives*
  • Glycerol / chemical synthesis
  • Glycerol / chemistry
  • Intracellular Space
  • Mice
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Polyethylene Glycols / chemical synthesis
  • Polyethylene Glycols / chemistry*
  • Polymers / chemical synthesis
  • Polymers / chemistry*

Substances

  • Decanoates
  • Polymers
  • poly(glycerol-sebacate)
  • Polyethylene Glycols
  • Glycerol