In vivo efficacy and properties of semisolid formulations containing panthenol

J Cosmet Dermatol. 2019 Feb;18(1):346-354. doi: 10.1111/jocd.12527. Epub 2018 Mar 25.


Background: Panthenol is an active substance used in dermatology to protect the health of the skin, to treat defects in the morphology of the stratum corneum. In cosmetology, hydrating, softening, and barrier function of panthenol are utilized. Detailed studies evaluating the efficacy of panthenol in cosmetic and pharmaceutical semisolid formulations and establishing its optimum concentration are needed.

Objectives: To investigate whether an addition of 5-13 wt% panthenol in o/w and w/o emulsions increases hydration and supports the barrier properties of the skin. Rheological properties and sensory analysis of prepared formulations are supplemented.

Methods: Noninvasive instrumental methods in vivo were used. The hydration and barrier effect of semisolid formulations on the skin were observed for 48 hour; testing was conducted on 40 women. The effect was compared with formulations without any content of panthenol. The rheological and organoleptic properties of the formulations were evaluated.

Results: After applying either form of the formulations containing 7-11 wt% of panthenol hydration of the skin increased, transepidermal water loss decreased. pH of the skin shifted toward neutral after application of tested formulations. The rheological properties of the formulations were influenced by the type of vehicle, the amount of panthenol, and temperature. Sensory evaluation of both semisolid forms revealed statistically significant differences in o/w formulations with regard to spreadability.

Conclusions: The presence of panthenol in an o/w and w/o semisolid formulations significantly enhances skin barrier repair and hydration of the stratum corneum. Better vehicle for the active substance as regards hydration proved o/w formulations.

Keywords: TEWL; formulation; panthenol; rheology; semisolid; sensory analysis; skin hydration.

MeSH terms

  • Adult
  • Cosmetics / pharmacology
  • Dermatologic Agents / pharmacology*
  • Drug Compounding
  • Emulsions / pharmacology
  • Epidermis / drug effects
  • Epidermis / physiology*
  • Female
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Middle Aged
  • Pantothenic Acid / analogs & derivatives*
  • Pantothenic Acid / pharmacology
  • Rheology
  • Sensation / drug effects
  • Skin Physiological Phenomena / drug effects*
  • Water / metabolism*
  • Water Loss, Insensible / drug effects
  • Young Adult


  • Cosmetics
  • Dermatologic Agents
  • Emulsions
  • Water
  • Pantothenic Acid
  • dexpanthenol