Soy undecapeptide induces Drosophila hind leg grooming via dopamine receptor

Biochem Biophys Res Commun. 2018 May 15;499(3):454-458. doi: 10.1016/j.bbrc.2018.03.162. Epub 2018 Mar 27.


β-Conglycinin α subunit (323-333) [βCGα(323-333)] is an exogenous neuromodulating undecapeptide found from enzymatic digest of β-conglycinin, a soy major storage protein by mice behavior tests. We investigated effect of βCGα(323-333) on Drosophila behavior. Oral administration of βCGα(323-333) in Drosophila increased hind leg grooming, which may act through specific sets of neurons. It was reported that dopamine receptor (DopR) meditates hind leg grooming, and we tested involvement of DopR in βCGα(323-333)-induced hind leg grooming by using DopR knockout flies. In the wild type but not in the DopR-knockout flies, βCGα(323-333) increased hind leg grooming. These results suggest that βCGα(323-333) induces hind leg grooming via activating the DopR. This is the first report showing that exogenously administered peptide changes fly behaviors.

Keywords: Behavior; Dopamine receptor; Drosophila; Soy peptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Plant / pharmacology
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / drug effects
  • Drosophila melanogaster / physiology*
  • Extremities / physiology*
  • Gene Knockdown Techniques
  • Globulins / pharmacology
  • Grooming / drug effects*
  • Oligopeptides / pharmacology*
  • Receptors, Dopamine / metabolism*
  • Seed Storage Proteins / pharmacology
  • Soybean Proteins / pharmacology
  • Soybeans / chemistry*


  • Antigens, Plant
  • Dop1R1 protein, Drosophila
  • Drosophila Proteins
  • Globulins
  • Oligopeptides
  • Receptors, Dopamine
  • Seed Storage Proteins
  • Soybean Proteins
  • beta-conglycinin protein, Glycine max