Topical Gentamicin for the Treatment of Genetic Skin Diseases

J Invest Dermatol. 2018 Apr;138(4):731-734. doi: 10.1016/j.jid.2017.12.008.

Abstract

Clinical application of topical gentamicin is a worthwhile option to investigate further for Nagashima-type palmoplantar keratosis and other genetic skin diseases caused by nonsense mutations. It is especially interesting to study gentamicin 1B because it may be more efficacious than other gentamicin components. Topical gentamicin has an acceptable safety profile, although prospective tracking of antibiotic resistance is warranted.

Publication types

  • Comment

MeSH terms

  • Codon, Nonsense
  • Gentamicins
  • Humans
  • Keratoderma, Palmoplantar*
  • Nonsense Mediated mRNA Decay
  • Prospective Studies
  • Serpins / genetics*

Substances

  • Codon, Nonsense
  • Gentamicins
  • SERPINB7 protein, human
  • Serpins