Chloroquine-induced cardiomyopathy

Arch Pathol Lab Med. 1987 Oct;111(10):953-6.


Biventricular hypertrophy and failure developed in two patients during treatment of systemic lupus erythematosus with chloroquine phosphate. In both patients, morphologic analysis of the myocardium, obtained by a right ventricular endomyocardial biopsy in one patient and at autopsy in the other, revealed accumulations of electron-dense concentric and parallel lamellae and curvilinear bodies within cardiac myocytes. These deposits were similar to those reported in chloroquine-induced skeletal myopathy and were considered to represent evidence of chloroquine-induced cardiotoxicity rather than a cardiovascular manifestation of the underlying disease. Clinical awareness and an endomyocardial biopsy specimen are necessary for the appropriate diagnosis of chloroquine-induced cardiomyopathy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Cardiomegaly / chemically induced*
  • Cardiomegaly / pathology
  • Chloroquine / adverse effects
  • Chloroquine / analogs & derivatives*
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / drug therapy*
  • Microscopy, Electron
  • Muscles / pathology
  • Myocardium / pathology


  • Anti-Inflammatory Agents, Non-Steroidal
  • chloroquine diphosphate
  • Chloroquine