Waking up muscle stem cells: PI3K signalling is ringing

EMBO J. 2018 Apr 13;37(8):e99297. doi: 10.15252/embj.201899297. Epub 2018 Mar 26.


Adult skeletal muscle injury instructs endogenous quiescent stem cells to activate for repair. The pathways involved in this activation remain poorly understood. An elegant study by Wang et al (2018) combine mouse molecular genetics with muscle regeneration experiments, cell culture and transcriptomic analysis to show that early activation depends on a PI3K‐mTORC1‐Jun/FoxOs signalling axis.

Publication types

  • Comment

MeSH terms

  • Adult
  • Humans
  • Phosphatidylinositol 3-Kinases*
  • Signal Transduction*
  • Stem Cells


  • Phosphatidylinositol 3-Kinases