LY165163 and 8-OH-DPAT have agonist effects on a serotonin responsive muscle of Aplysia

Eur J Pharmacol. 1987 Jul 9;139(2):247-50. doi: 10.1016/0014-2999(87)90259-7.

Abstract

Serotonin enhances acetylcholine-elicited contractions of buccal muscle E1 of Aplysia. To characterize the serotonin receptor, actions of ligands of specific serotonin receptor subtypes were examined. Ketanserin, an antagonist at 5-HT2 receptors, had little effect. Two 5-HT1A ligands, LY165163 and 8-OH-DPAT, mimicked the effect of serotonin, although with slower kinetics. This suggests that the peripheral serotonin receptor in Aplysia more closely resembles 5-HT1 than 5-HT2 receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Acetylcholine / pharmacology
  • Animals
  • Aplysia / physiology*
  • In Vitro Techniques
  • Ketanserin / pharmacology
  • Muscle Contraction / drug effects
  • Muscle, Smooth / drug effects*
  • Naphthalenes / pharmacology*
  • Piperazines / pharmacology*
  • Serotonin / pharmacology
  • Serotonin / physiology*
  • Tetrahydronaphthalenes / pharmacology*

Substances

  • Naphthalenes
  • Piperazines
  • Tetrahydronaphthalenes
  • Serotonin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • LY 165163
  • Ketanserin
  • Acetylcholine