Abstract
Serotonin enhances acetylcholine-elicited contractions of buccal muscle E1 of Aplysia. To characterize the serotonin receptor, actions of ligands of specific serotonin receptor subtypes were examined. Ketanserin, an antagonist at 5-HT2 receptors, had little effect. Two 5-HT1A ligands, LY165163 and 8-OH-DPAT, mimicked the effect of serotonin, although with slower kinetics. This suggests that the peripheral serotonin receptor in Aplysia more closely resembles 5-HT1 than 5-HT2 receptors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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8-Hydroxy-2-(di-n-propylamino)tetralin
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Acetylcholine / pharmacology
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Animals
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Aplysia / physiology*
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In Vitro Techniques
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Ketanserin / pharmacology
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects*
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Naphthalenes / pharmacology*
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Piperazines / pharmacology*
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Serotonin / pharmacology
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Serotonin / physiology*
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Tetrahydronaphthalenes / pharmacology*
Substances
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Naphthalenes
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Piperazines
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Tetrahydronaphthalenes
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Serotonin
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8-Hydroxy-2-(di-n-propylamino)tetralin
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LY 165163
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Ketanserin
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Acetylcholine