Gut Microbiota and Type 1 Diabetes

doi:10.3390/ijms19040995

Review

. 2018 Mar 27;19(4):995.

doi: 10.3390/ijms19040995.

Gut Microbiota and Type 1 Diabetes

Hui Han^{1

2}, Yuying Li^{3

4}, Jun Fang⁵, Gang Liu⁶, Jie Yin^{7

8}, Tiejun Li^{9

10}, Yulong Yin^{11

12}

Affiliations

¹ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. hanhui16@mails.ucas.ac.cn.
² University of Chinese Academy of Sciences, Beijing 100039, China. hanhui16@mails.ucas.ac.cn.
³ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. liyuying@mails.ucas.ac.cn.
⁴ University of Chinese Academy of Sciences, Beijing 100039, China. liyuying@mails.ucas.ac.cn.
⁵ College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. fangjun1973@hunau.edu.cn.
⁶ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. gangle.liu@gmail.com.
⁷ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. yinjie2014@126.com.
⁸ University of Chinese Academy of Sciences, Beijing 100039, China. yinjie2014@126.com.
⁹ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. tjli@isa.ac.cn.
¹⁰ Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China. tjli@isa.ac.cn.
¹¹ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. yinyulonsg@isa.ac.cn.
¹² Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China. yinyulonsg@isa.ac.cn.

PMID: 29584630
PMCID: PMC5979537
DOI: 10.3390/ijms19040995

Review

Gut Microbiota and Type 1 Diabetes

Hui Han et al. Int J Mol Sci. 2018.

. 2018 Mar 27;19(4):995.

doi: 10.3390/ijms19040995.

Authors

Hui Han^{1

2}, Yuying Li^{3

4}, Jun Fang⁵, Gang Liu⁶, Jie Yin^{7

8}, Tiejun Li^{9

10}, Yulong Yin^{11

12}

Affiliations

¹ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. hanhui16@mails.ucas.ac.cn.
² University of Chinese Academy of Sciences, Beijing 100039, China. hanhui16@mails.ucas.ac.cn.
³ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. liyuying@mails.ucas.ac.cn.
⁴ University of Chinese Academy of Sciences, Beijing 100039, China. liyuying@mails.ucas.ac.cn.
⁵ College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. fangjun1973@hunau.edu.cn.
⁶ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. gangle.liu@gmail.com.
⁷ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. yinjie2014@126.com.
⁸ University of Chinese Academy of Sciences, Beijing 100039, China. yinjie2014@126.com.
⁹ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. tjli@isa.ac.cn.
¹⁰ Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China. tjli@isa.ac.cn.
¹¹ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410128, China. yinyulonsg@isa.ac.cn.
¹² Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China. yinyulonsg@isa.ac.cn.

PMID: 29584630
PMCID: PMC5979537
DOI: 10.3390/ijms19040995

Abstract

Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed.

Keywords: diet; gut microbiota; hormones; immune response; type 1 diabetes.

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Conflict of interest statement

The authors have declared no conflict of interest.

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References

1. International Diabetes Federation . IDF Diabetes Atlas. 7th ed. International Diabetes Federation; Brussels, Belgium: 2015.
1. Reynolds K.A., Helgeson V.S. Children with diabetes compared to peers: Depressed? Distressed? A meta-analytic review. Ann. Behav. Med. 2011;42:29–41. doi: 10.1007/s12160-011-9262-4. - DOI - PMC - PubMed
1. Hagger V., Hendrieckx C., Sturt J., Skinner T.C., Speight J. Diabetes Distress among Adolescents with Type 1 Diabetes: A Systematic Review. Curr. Diabetes Rep. 2016;16:9. doi: 10.1007/s11892-015-0694-2. - DOI - PubMed
1. Martyn-Nemeth P., Schwarz Farabi S., Mihailescu D., Nemeth J., Quinn L. Fear of hypoglycemia in adults with type 1 diabetes: Impact of therapeutic advances and strategies for prevention—A review. J. Diabetes Its Complic. 2016;30:167–177. doi: 10.1016/j.jdiacomp.2015.09.003. - DOI - PubMed
1. Pociot F., Lernmark A. Genetic risk factors for type 1 diabetes. Lancet. 2016;387:2331–2339. doi: 10.1016/S0140-6736(16)30582-7. - DOI - PubMed

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[1] International Diabetes Federation . IDF Diabetes Atlas. 7th ed. International Diabetes Federation; Brussels, Belgium: 2015.

[2] International Diabetes Federation . IDF Diabetes Atlas. 7th ed. International Diabetes Federation; Brussels, Belgium: 2015.

[3] Reynolds K.A., Helgeson V.S. Children with diabetes compared to peers: Depressed? Distressed? A meta-analytic review. Ann. Behav. Med. 2011;42:29–41. doi: 10.1007/s12160-011-9262-4. - DOI - PMC - PubMed

[4] Reynolds K.A., Helgeson V.S. Children with diabetes compared to peers: Depressed? Distressed? A meta-analytic review. Ann. Behav. Med. 2011;42:29–41. doi: 10.1007/s12160-011-9262-4. - DOI - PMC - PubMed

[5] Hagger V., Hendrieckx C., Sturt J., Skinner T.C., Speight J. Diabetes Distress among Adolescents with Type 1 Diabetes: A Systematic Review. Curr. Diabetes Rep. 2016;16:9. doi: 10.1007/s11892-015-0694-2. - DOI - PubMed

[6] Hagger V., Hendrieckx C., Sturt J., Skinner T.C., Speight J. Diabetes Distress among Adolescents with Type 1 Diabetes: A Systematic Review. Curr. Diabetes Rep. 2016;16:9. doi: 10.1007/s11892-015-0694-2. - DOI - PubMed

[7] Martyn-Nemeth P., Schwarz Farabi S., Mihailescu D., Nemeth J., Quinn L. Fear of hypoglycemia in adults with type 1 diabetes: Impact of therapeutic advances and strategies for prevention—A review. J. Diabetes Its Complic. 2016;30:167–177. doi: 10.1016/j.jdiacomp.2015.09.003. - DOI - PubMed

[8] Martyn-Nemeth P., Schwarz Farabi S., Mihailescu D., Nemeth J., Quinn L. Fear of hypoglycemia in adults with type 1 diabetes: Impact of therapeutic advances and strategies for prevention—A review. J. Diabetes Its Complic. 2016;30:167–177. doi: 10.1016/j.jdiacomp.2015.09.003. - DOI - PubMed

[9] Pociot F., Lernmark A. Genetic risk factors for type 1 diabetes. Lancet. 2016;387:2331–2339. doi: 10.1016/S0140-6736(16)30582-7. - DOI - PubMed

[10] Pociot F., Lernmark A. Genetic risk factors for type 1 diabetes. Lancet. 2016;387:2331–2339. doi: 10.1016/S0140-6736(16)30582-7. - DOI - PubMed

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Gut Microbiota and Type 1 Diabetes

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Gut Microbiota and Type 1 Diabetes

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