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. 2018 Mar 27;17(1):59.
doi: 10.1186/s12944-018-0704-x.

Powdered Black Cumin Seeds Strongly Improves Serum Lipids, Atherogenic Index of Plasma and Modulates Anthropometric Features in Patients With Hashimoto's Thyroiditis

Free PMC article

Powdered Black Cumin Seeds Strongly Improves Serum Lipids, Atherogenic Index of Plasma and Modulates Anthropometric Features in Patients With Hashimoto's Thyroiditis

Mahdieh Abbasalizad Farhangi et al. Lipids Health Dis. .
Free PMC article


Background: Hashimoto's thyroiditis is associated with serious alterations in serum lipids and glucose homeostasis. The aims of the current study were to evaluate the effect of powdered Nigella sativa on serum lipids, glucose homeostasis and anthropometric variables in patients with Hashimoto's thyroiditis.

Methods: Forty patients with Hashimoto's thyroiditis, aged between 22 and 50 years old, participated in the trial and were randomly allocated into two groups of intervention and control receiving powdered Nigella sativa or placebo daily for 8 weeks. Serum lipids, glucose homeostasis, and anthropometric variables were evaluated at baseline and after intervention.

Results: Treatment with Nigella sativa significantly reduced body weight and body mass index (BMI). Serum concentrations of low density lipoprotein cholesterol (LDL) and triglyceride (TG) also decreased in Nigella sativa-treated group after 8 weeks; while serum high density lipoprotein cholesterol (HDL) significantly increased after treatment with Nigella sativa (P < 0.05). None of these changes had been observed in placebo treated group. Serum Nesfatin-1 concentrations was in inverse relationship with serum triglyceride (TG) (r = - 0.31, P = 0.04).

Conclusions: Giving attention to the potent beneficial effects of powdered black cumin seeds in improving serum lipid profile and anthropometric features in patients with Hashimoto's thyroiditis, this medicinal plant could be considered as a beneficial herbal supplement alongside with the disease- specific medications including Levothyroxine in management of Hashimoto's thyroiditis- related metabolic abnormalities.

Trial registration: Iranian registry of clinical trials (registration number IRCT2014090819082N2 - Registered 2014-09-29).

Keywords: Black cumin; Glucose homeostasis; Hashimoto’s thyroiditis; Lipid profile; Nigella sativa.

Conflict of interest statement

Ethics approval and consent to participate

All participants signed a written informed consent approved by the Institutional Review Board of Tabriz University of Medical Sciences. The study design and protocol was approved by the ethical committee of Tabriz University of Medical Sciences (Project number: 93173). The study has also been registered in Iranian registry of clinical trials (registration number IRCT2014090819082N2- Registered 2014-09-29).

Consent for publication

Not applicable.

Competing interests

The authors declare that there is no competing of interest.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


Fig. 1
Fig. 1
Flow diagram of subject recruitment
Fig. 2
Fig. 2
Relationship between serum Nesfatin-1 and triglyceride concentrations in total participants

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    1. Chistiakov DA. Immunogenetics of Hashimoto's thyroiditis. J Autoimmune Dis. 2005;2(1):1–21. - PMC - PubMed
    1. Jalilzadeh S, Bahrami A, Eftekhar-Sadat B, Pezeshki Z, Salek Zamani Y, Mobasseri M. Electrodiagnostic changes in patient with subclinical hypothyroidism. Med J Tabriz University of Med Sci Health Serv. 2007;29(1):11–20.
    1. Wang C, Crapo LM. The epidemiology of thyroid disease and implications for screening. Endocrinol Metab Clin N Am. 1997;26:189–218. - PubMed
    1. Tunbridge WM, Vanderpump MP. Population screening for autoimmune thyroid disease. Endocrinol Metab Clin N Am. 2000;29:239–253. - PubMed
    1. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey. Clin Endocrinol. 1995;43:55–69. - PubMed