Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype

Hepatol Int. 2018 Mar;12(2):83-86. doi: 10.1007/s12072-018-9855-0. Epub 2018 Mar 27.


Although guidelines are available for hereditary hemochromatosis, a high percentage of the recommendations within them are not shared between the different guidelines. Our main aim is to provide an objective, simple, brief, and practical set of recommendations about therapeutic aspects of HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype, based on the published scientific studies and guidelines, in a form that is reasonably comprehensible to patients and people without medical training. This final version was approved at the Hemochromatosis International meeting on 12th May 2017 in Los Angeles.

Publication types

  • Practice Guideline

MeSH terms

  • Chelation Therapy / methods
  • Diet
  • Female
  • Hemochromatosis Protein / genetics
  • Hemochromatosis* / genetics
  • Hemochromatosis* / therapy
  • Homozygote
  • Humans
  • Male
  • Phlebotomy / methods


  • Hemochromatosis Protein