Salbutamol and ipratropium in partially reversible airway obstruction

Br J Dis Chest. 1987 Jan;81(1):55-61. doi: 10.1016/0007-0971(87)90108-2.


Thirty-six patients with a combination of reversible and persistent airway obstruction were treated with ipratropium bromide, salbutamol and a combination of both in high dose by nebulizer after a control period of rimiterol. The ipratropium and salbutamol were given double blind in random order and the dose of each was the same during the combination periods. Although there was a significant increase in pulmonary function in all treatment periods over the control, only the 6-minute walking distance was significantly improved in the combination period over treatment with salbutamol and ipratropium individually. This was not due to a progressive rise with time irrespective of the therapy. The results are compatible with a small number of patients benefiting from combination therapy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Albuterol / therapeutic use*
  • Atropine Derivatives / therapeutic use*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Ipratropium / therapeutic use*
  • Lung Diseases, Obstructive / drug therapy*
  • Lung Diseases, Obstructive / physiopathology
  • Male
  • Middle Aged
  • Physical Exertion
  • Respiratory Function Tests


  • Atropine Derivatives
  • Ipratropium
  • Albuterol