Genetic and molecular aspects of androgenetic alopecia

Indian J Dermatol Venereol Leprol. May-Jun 2018;84(3):263-268. doi: 10.4103/ijdvl.IJDVL_262_17.

Abstract

Androgenetic alopecia is the most common form of progressive hair loss in humans. A genetic predisposition and hormonal status are considered as major risk factors for this condition. Several recent advances in molecular biology and genetics have increased our understanding of the mechanisms of hair loss in androgenetic alopecia. We review these advances and examine the trends in the genetic and molecular aspects of androgenetic alopecia.

Keywords: Androgenetic alopecia; genetics; molecular analysis.

Publication types

  • Review

MeSH terms

  • Alopecia / genetics*
  • Alopecia / metabolism*
  • Alopecia / therapy
  • Epigenesis, Genetic / drug effects
  • Epigenesis, Genetic / physiology*
  • Finasteride / administration & dosage
  • Genetic Predisposition to Disease / genetics*
  • Genome-Wide Association Study / methods
  • Hair / drug effects
  • Hair / growth & development
  • Hair / metabolism
  • Hair Follicle / drug effects
  • Hair Follicle / growth & development
  • Hair Follicle / metabolism*
  • Humans
  • Minoxidil / administration & dosage
  • Receptors, Androgen / genetics
  • Receptors, Androgen / metabolism

Substances

  • Receptors, Androgen
  • Finasteride
  • Minoxidil