A Potential Adjuvant Agent of Chemotherapy: Sepia Ink Polysaccharides

Mar Drugs. 2018 Mar 28;16(4):106. doi: 10.3390/md16040106.


Sepia ink polysaccharide (SIP) isolated from squid and cuttlefish ink is a kind of acid mucopolysaccharide that has been identified in three types of primary structures from squid (Illex argentinus and Ommastrephes bartrami), cuttlefish Sepiella maindroni, and cuttlefish Sepia esculenta ink. Although SIP has been proved to be multifaceted, most of the reported evidence has illuminated its chemopreventive and antineoplastic activities. As a natural product playing a role in cancer treatment, SIP may be used as chemotherapeutic ancillary agent or functional food. Based on the current findings on SIP, we have summarized four topics in this review, including: chemopreventive, antineoplastic, chemosensitive, and procoagulant and anticoagulant activities, which are correlative closely with the actions of anticancer agents on cancer patients, such as anticancer, toxicity and thrombogenesis, with the latter two actions being common causes of death in cancer cases exposed to chemotherapeutic agents.

Keywords: Sepia ink polysaccharides; anticoagulation; antitumour; chemoprevention; chemosensitization.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemotherapy, Adjuvant
  • Ink*
  • Polysaccharides / chemistry*
  • Sepia / chemistry*


  • Polysaccharides