Although I currently lead a team of cardiovascular investigators at the University of Cincinnati, my beginnings were humble, as I came from a farming family in a small village in the southernmost part of India. The path I traveled was arduous, and it involved significant struggles, but I’ve finally realized many of my career goals. My story recapitulates the essence of some of the common career hurdles that many early-career cardiovascular scientists must overcome these days, and in this article, these career hurdles are discussed, as well as some strategies to overcome them.