Metabolic Regulation of Methionine Restriction in Diabetes

Mol Nutr Food Res. 2018 May;62(10):e1700951. doi: 10.1002/mnfr.201700951.


Although the effects of dietary methionine restriction have been investigated in the physiology of aging and diseases related to oxidative stress, the relationship between methionine restriction (MR) and the development of metabolic disorders has not been explored extensively. This review summarizes studies of the possible involvement of dietary methionine restriction in improving insulin resistance, glucose homeostasis, oxidative stress, lipid metabolism, the pentose phosphate pathway (PPP), and inflammation, with an emphasis on the fibroblast growth factor 21 and protein phosphatase 2A signals and autophagy in diabetes. Diets deficient in methionine may be a useful nutritional strategy in patients with diabetes.

Keywords: diabetes; insulin; methionine restriction; oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy
  • Diabetes Mellitus / diet therapy*
  • Diabetes Mellitus / metabolism*
  • Glucose / metabolism
  • Humans
  • Insulin Resistance
  • Lipid Metabolism
  • Methionine / administration & dosage
  • Methionine / metabolism*
  • Oxidative Stress
  • Pentose Phosphate Pathway


  • Methionine
  • Glucose