European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Alzheimers Dement. 2018 Jun;14(6):837-842. doi: 10.1016/j.jalz.2018.02.010. Epub 2018 Mar 28.


Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.

Methods: A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.

Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.

Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.

Keywords: Clinical trial; EPAD; Participant recruitment; Preclinical AD; Prodromal AD; Research registry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / prevention & control*
  • Biomarkers
  • Clinical Trials as Topic*
  • Europe
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Patient Selection*
  • Prodromal Symptoms
  • Registries*
  • Risk Factors


  • Biomarkers