Nonacetaminophen Drug-Induced Acute Liver Failure

Clin Liver Dis. 2018 May;22(2):301-324. doi: 10.1016/j.cld.2018.01.006. Epub 2018 Feb 7.


Acute liver failure of all causes is diagnosed in between 2000 and 2500 patients annually in the United States. Drug-induced acute liver failure is the leading cause of acute liver failure, accounting for more than 50% of cases. Nonacetaminophen drug injury represents 11% of all cases in the latest registry from the US Acute Liver Failure Study Group. Although rare, acute liver failure is clinically dramatic when it occurs, and requires a multidisciplinary approach to management. In contrast with acetaminophen-induced acute liver failure, non-acetaminophen-induced acute liver failure has a more ominous prognosis with a lower liver transplant-free survival.

Keywords: Acute liver failure; Drug-induced liver injury; Nonacetaminophen drug-induced liver injury.

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Chemical and Drug Induced Liver Injury / complications*
  • Humans
  • Liver Failure, Acute / chemically induced*
  • Liver Failure, Acute / diagnosis
  • Liver Failure, Acute / epidemiology
  • Liver Failure, Acute / therapy
  • Middle Aged