Association between asthma and lung function in adolescents born very preterm: results of the EPIPAGE cohort study

Thorax. 2018 Dec;73(12):1174-1176. doi: 10.1136/thoraxjnl-2017-211115. Epub 2018 Mar 31.


Prematurity and bronchopulmonary dysplasia (BPD) affect long-term lung function. We studied the respiratory outcome of adolescents born very preterm and controls from the Etude EPIdémiologique sur les Petits Ages Gestationnels cohort and analysed their current lung function in relation to asthma symptoms (categorised in three age groups) from birth. In models including BPD, asthma at each age and confounding factors in the preterm group, BPD and preschool wheeze were the only independent variables associated with FEV1 Preschool wheeze is an independent factor associated with FEV1 impairment in adolescents born very preterm. These results highlight the need for optimal management of early respiratory symptoms in preterm-born infants. TRIAL REGISTRATION NUMBER: Results, NCT01424553.

Keywords: paediatric asthma; paediatric lung disaese.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asthma / epidemiology*
  • Asthma / physiopathology*
  • Breath Tests
  • Bronchopulmonary Dysplasia / epidemiology*
  • Bronchopulmonary Dysplasia / physiopathology
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Forced Expiratory Volume
  • France / epidemiology
  • Humans
  • Male
  • Nitrogen Oxides / analysis
  • Premature Birth / epidemiology*
  • Premature Birth / physiopathology
  • Prospective Studies
  • Respiratory Sounds / physiopathology*
  • Sex Factors
  • Term Birth / physiology


  • Nitrogen Oxides

Associated data