Biophysical Properties of Extracellular Matrix: Linking Obesity and Cancer

Trends Cancer. 2018 Apr;4(4):271-273. doi: 10.1016/j.trecan.2018.02.001. Epub 2018 Mar 10.


Obesity has been associated with increased severity of diagnoses for several types of cancer, and recent evidence suggests that the mechanism by which obese tissues contribute to cancer progression involves the extracellular matrix (ECM). Understanding the physicochemical differences between lean and obese ECM, and how cancer cells respond to these differences, promises therapeutic insight.

Keywords: cancer; extracellular matrix; obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adipokines / metabolism
  • Adipose Tissue / metabolism
  • Adipose Tissue / pathology*
  • Biophysical Phenomena*
  • Carcinogenesis / metabolism
  • Carcinogenesis / pathology
  • Disease Progression
  • Extracellular Matrix / pathology*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Obesity / metabolism*


  • Adipokines