Petroclival tension pneumocephalus: an unrivalled life threatening complication linked to molecular-targeted therapy

Br J Neurosurg. 2018 Apr 2;1-3. doi: 10.1080/02688697.2018.1457772. Online ahead of print.


A 73-year-old man with a petroclival tumor (metastatic renal cell carcinoma) presented with a progressive consciousness disturbance attributed to tension pneumocephalus during molecular-targeted therapy following low-dose fractionated radiotherapy for a petroclival tumor. The skull base defect was successfully reconstructed vi an endoscopic endonasal approach.

Keywords: Tension pneumocephalus; molecular-targeted therapy; oncology team; petroclival tumor; radiotherapy.