Antitumor and Immunomodulatory Activities of Ganoderma Lucidum Polysaccharides in Glioma-Bearing Rats

Integr Cancer Ther. 2018 Sep;17(3):674-683. doi: 10.1177/1534735418762537. Epub 2018 Apr 2.


Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of G lucidum, which have been recognized as a promising natural source of immunomodulatory and anticancer compounds. It remains unknown whether the GL-PS have any immunomodulatory and anticancer effects on brain glioma. This study was designed to identify and characterize the antitumor action and influence of immune system of GL-PS in glioma-bearing rats. Results showed that GL-PS increased the concentration of serum interleukin-2, tumor necrosis factor-α, and interferon-γ, and enhanced the cytotoxic activity of natural killer cells and T cells, promoting the functional maturation of dendritic cells, thus resulting in the inhibition of glioma growth and prolonged survival of rats. Therefore, GL-PS may be potentially useful as part of the treatment regimen to regulate host immune responses and increase the antitumor effects of immunotherapy for glioma.

Keywords: Ganoderma lucidum polysaccharides; antitumor; glioma; immunomodulation; tumor-bearing rat model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Dendritic Cells / drug effects
  • Dendritic Cells / metabolism
  • Disease Models, Animal
  • Glioma / blood
  • Glioma / drug therapy*
  • Glioma / metabolism
  • Humans
  • Immunologic Factors / pharmacology*
  • Interferon-gamma / blood
  • Interleukin-2 / blood
  • K562 Cells
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / metabolism
  • Male
  • Polysaccharides / pharmacology*
  • Rats
  • Rats, Inbred F344
  • Reishi / chemistry*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / metabolism
  • Tumor Necrosis Factor-alpha / blood


  • Antineoplastic Agents
  • Immunologic Factors
  • Interleukin-2
  • Polysaccharides
  • Tumor Necrosis Factor-alpha
  • Interferon-gamma