Anxiolytic Therapy: A Paradigm of Successful Mitochondrial Pharmacology

Trends Pharmacol Sci. 2018 May;39(5):437-439. doi: 10.1016/j.tips.2018.02.008. Epub 2018 Mar 30.

Abstract

The complex biochemistry and dynamic structure of mitochondria have prevented them from being prominent pharmacological targets. New mechanistic understanding of cholesterol transport and associated neurosteroidogenesis is providing evidence on therapeutic outcomes in mental disorders that is achievable via mitochondrial pharmacology. This warrants general attention on mitochondrial pharmacology to inform therapies.

Keywords: GABA and TSPO; mitochondria; neurosteroidogenesis; pharmacology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / metabolism
  • Humans
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Neurotransmitter Agents / biosynthesis
  • Neurotransmitter Agents / pharmacology*
  • Receptors, GABA / metabolism

Substances

  • Anti-Anxiety Agents
  • Neurotransmitter Agents
  • Receptors, GABA