B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity

Abstract

Pyridox(am)ine-5-phosphate oxidase deficiency is an inborn error of vitamin B₆ metabolism that is characterized by neonatal seizures, requiring lifelong therapy with pyridoxal-5-phosphate. We present the first case of a patient with pyridox(am)ine-5-phosphate oxidase deficiency and mild hemophilia A, whose bleeding symptoms were exacerbated by the vitamin B₆ therapy essential for his epileptic disorder. This report expands the spectrum of known vitamin B₆ toxicity and demonstrates a need for vigilance in monitoring for bleeding symptoms in patients requiring pyridoxine or pyridoxal-5-phosphate supplementation.