Switching from fetal to adult hemoglobin

Nat Genet. 2018 Apr;50(4):478-480. doi: 10.1038/s41588-018-0094-z.


The switch from fetal to adult hemoglobin relies on repression or silencing of the upstream γ-globin gene, but identification of the transcriptional repressors that bind to the sites at which a cluster of naturally occurring variants associated with HPFH (hereditary persistence of fetal hemoglobin) are found has been elusive. A new study provides mechanistic evidence for the direct binding of BCL11A and ZBTB7A, two previously identified γ-globin gene repressors.

Publication types

  • Comment

MeSH terms

  • Adult
  • Cell Line, Tumor
  • DNA-Binding Proteins*
  • Hemoglobins
  • Humans
  • Mutation
  • Transcription Factors*


  • DNA-Binding Proteins
  • Hemoglobins
  • Transcription Factors