Deoxynivalenol as potential modulator of human steroidogenesis

Kinga Anna Urbanek; Dominika Ewa Habrowska-Górczyńska; Karolina Kowalska; Anna Stańczyk; Kamila Domińska; Agnieszka Wanda Piastowska-Ciesielska

doi:10.1002/jat.3623

Deoxynivalenol as potential modulator of human steroidogenesis

J Appl Toxicol. 2018 Dec;38(12):1450-1459. doi: 10.1002/jat.3623. Epub 2018 Apr 3.

Authors

Kinga Anna Urbanek¹, Dominika Ewa Habrowska-Górczyńska¹, Karolina Kowalska¹, Anna Stańczyk², Kamila Domińska³, Agnieszka Wanda Piastowska-Ciesielska¹

Affiliations

¹ Laboratory of Cell Cultures and Genomic Analysis, Department of Comparative Endocrinology, Medical University of Lodz, Poland.
² Laboratory of Cellular and Molecular Biology, Medical University of Lodz, Poland.
³ Department of Comparative Endocrinology, Medical University of Lodz, Poland.

PMID: 29611633
DOI: 10.1002/jat.3623

Abstract

Deoxynivalenol (DON) is a type B trichothecene, produced by the Fusarium species. Exposure to DON might cause disruptive effects such as reduced weight gain, neuroendocrine changes and immune modulation in animals (rats, dogs, pigs). There is huge concern that similar effects can be observed in humans. DON is a potential regulator of intracellular steroidogenesis. It is also possible that DON will be involved in the regulation of miRNAs connected with steroidogenesis. This review summarizes the latest knowledge about the influence of DON on steroidogenesis and human hormonal balance.

Keywords: cancerogenesis; deoxynivalenol; miRNA; mycotoxin; steroidogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Crops, Agricultural / chemistry
Crops, Agricultural / microbiology
Endocrine Disruptors / analysis
Endocrine Disruptors / toxicity*
Fusarium / chemistry
Humans
Steroids / biosynthesis*
Trichothecenes / analysis
Trichothecenes / toxicity*

Substances

Endocrine Disruptors
Steroids
Trichothecenes
deoxynivalenol