Atrial natriuretic peptide deposited as atrial amyloid fibrils

Biochem Biophys Res Commun. 1987 Nov 13;148(3):1087-92. doi: 10.1016/s0006-291x(87)80243-7.

Abstract

Deposition of amyloid in the atria is exceedingly common in the aging heart. We have extracted amyloid fibrils from atria and purified a major protein which had N-terminal amino acid sequence identical to that of atrial natriuretic peptide (ANP). Antisera to ANP and to the amyloid fibril protein both labelled atrial muscle cells and atrial amyloid in an identical way.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging*
  • Amino Acid Sequence
  • Amino Acids / analysis
  • Amyloid / metabolism*
  • Atrial Natriuretic Factor / metabolism*
  • Chromatography, High Pressure Liquid
  • Heart Atria / metabolism*
  • Humans
  • Immunologic Techniques
  • Molecular Weight

Substances

  • Amino Acids
  • Amyloid
  • Atrial Natriuretic Factor