The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments

Cell. 1987 Dec 24;51(6):929-40. doi: 10.1016/0092-8674(87)90580-0.

Abstract

We establish that the position-specific antigen 2 (PS2), a Drosophila cell surface glycoprotein complex, is an invertebrate member of the vertebrate fibronectin receptor (integrin) family. New monoclonal antibodies show that in Drosophila embryos and larvae PS2 alpha subunits have a size of ca. 140 kd. Analysis of cDNA and genomic clones revealed that the canonical PS2 alpha subunit contains 1394 amino acids and has extensive homology to the heavy and light chains of integrin alpha subunits. The distribution of the PS2 antigen is regulated at the level of PS2 alpha subunit mRNA. In early Drosophila development the protein is restricted to mesoderm and appears to be involved in muscle attachment. We suggest that PS2, like vertebrate fibronectin receptors, mediates changes in cell shape and cell-extracellular matrix adhesion by binding to a basement membrane protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Surface / analysis*
  • Antigens, Surface / genetics
  • Base Sequence
  • Drosophila melanogaster / analysis*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / immunology
  • Integrins
  • Membrane Glycoproteins / analysis*
  • Membrane Glycoproteins / genetics
  • Mesoderm / analysis
  • Molecular Sequence Data
  • Muscles / analysis
  • Receptors, Fibronectin
  • Receptors, Immunologic
  • Transcription, Genetic

Substances

  • Antigens, Surface
  • Integrins
  • Membrane Glycoproteins
  • Receptors, Fibronectin
  • Receptors, Immunologic

Associated data

  • GENBANK/M19059