The NOD mouse as a model of type I diabetes

Crit Rev Immunol. 1987;8(1):49-81.

Abstract

Type 1 diabetes has been recognized as an organ-specific autoimmune disease. The NOD mouse showed a marked infiltration of T cells into the pancreatic islets and selectively destroyed B cells. The overt diabetes appeared in 90% of the females. Both T- and B-cell functions were markedly disturbed in the overt diabetes. Athymic NOD mice showed little incidence of insulitis. Some immunomodulators induced the overt diabetes. The NOD mouse has many similarities with diabetic profiles including biochemical, morphological, and immunological features of type 1 diabetes. Mice are familiar studies for genetic and immunological analyses. Therefore, the NOD mouse might be a useful model for elucidating etiopathogenesis of type 1 diabetes.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / therapy
  • Diabetes Mellitus, Experimental / genetics
  • Diabetes Mellitus, Experimental / immunology*
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / therapy
  • Female
  • Gonadal Steroid Hormones / physiology
  • Immunosuppressive Agents / therapeutic use
  • Islets of Langerhans / pathology
  • Islets of Langerhans Transplantation
  • Kidney / pathology
  • Lymphocytes / immunology
  • Lymphocytes / pathology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains / genetics
  • Mice, Mutant Strains / immunology
  • Mice, Mutant Strains / metabolism*
  • Niacinamide / therapeutic use
  • Obesity / complications
  • Pancreas / pathology
  • Prediabetic State / drug therapy
  • Prediabetic State / pathology
  • Rats
  • Rats, Inbred Strains / metabolism
  • Sex Factors
  • Thymus Gland / pathology

Substances

  • Gonadal Steroid Hormones
  • Immunosuppressive Agents
  • Niacinamide