Reexamining post-transplant lymphoproliferative disorders: Newly recognized and enigmatic types

Semin Diagn Pathol. 2018 Jul;35(4):236-246. doi: 10.1053/j.semdp.2018.02.001. Epub 2018 Mar 3.


Post-transplant lymphoproliferative disorders (PTLD) are a known risk for both solid organ transplant and stem cell transplant recipients. Overall transplant recipients have a six fold increase in risk for developing any kind of non-Hodgkin lymphoma and PTLDs occur in up to 10% of SOT recipients. Several new entities have been accepted or renamed in the 2018 update of the WHO classification of tumors of hematopoietic and lymphoid neoplasms, including florid follicular hyperplasia and extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT-lymphoma) (excluding common locations such as stomach and salivary gland). Other more rare types of PTLD have been reclassified including EBV-positive mucocutaneous ulcer, which is now a recognized diagnosis in its own right and should not be considered polymorphous PTLD. In this paper newly recognized PTLD entities and more unusual PTLDs will be examined.

Publication types

  • Review

MeSH terms

  • Epstein-Barr Virus Infections / classification
  • Epstein-Barr Virus Infections / diagnosis*
  • Epstein-Barr Virus Infections / pathology
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Iatrogenic Disease
  • Immunosuppression Therapy
  • Lymphoma, B-Cell, Marginal Zone / classification
  • Lymphoma, B-Cell, Marginal Zone / diagnosis*
  • Lymphoma, B-Cell, Marginal Zone / pathology
  • Lymphoproliferative Disorders / classification
  • Lymphoproliferative Disorders / diagnosis*
  • Lymphoproliferative Disorders / pathology
  • Organ Transplantation / adverse effects*
  • Transplant Recipients
  • Tumor Microenvironment