Rearrangements to the JP1, JP and JP2 segments in the human T-cell rearranging gamma gene (TRG gamma) locus

FEBS Lett. 1987 Nov 30;224(2):291-6. doi: 10.1016/0014-5793(87)80472-6.


In the human T-cell rearranging gamma (TRG gamma) locus, five joining (J) segments have been identified: J1, J2 and three additional segments JP, JP1 and JP2. We report the sequence of the germline JP1 segment and compare it with the other human and mouse J gamma segments. We also demonstrate that rearrangements to the three additional J gamma segments can be identified by hybridization of the KpnI digests to the J gamma 1 probe pH60. Since rearrangements to J1 or J2 can be assigned, using the same pH60 probe, to one of the nine variable (V) gamma genes known to rearrange [(1987) EMBO J. 6, 1945-1950], our results show that a unique probe can detect all the TRG gamma rearrangements and be particularly useful for assessing the preferential usage of V gamma and J gamma segments in the TRG gamma-expressing cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Genes
  • Humans
  • Mice
  • Molecular Sequence Data
  • Receptors, Antigen, T-Cell / genetics*
  • Receptors, Antigen, T-Cell, gamma-delta
  • Regulatory Sequences, Nucleic Acid


  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, gamma-delta

Associated data

  • GENBANK/X08084