Non-comedogenic and non-acnegenic claim substantiation

J Cosmet Sci. Jul/Aug 2017;68(4):253-256.


There are currently two methods to evaluate comedogenecity. One is the inexpensive human model developed by Mills and Kligman and modified by others. The second is the more costly human clinical trial, which is the gold standard for comedogenesis and to which the human model is compared. The qualification of each method to support the comedogenecity claim is evaluated and contrasted.

MeSH terms

  • Acne Vulgaris / chemically induced*
  • Cosmetics / adverse effects*
  • Dermatologic Agents / adverse effects*
  • Humans
  • Models, Biological
  • Reproducibility of Results
  • Skin / drug effects


  • Cosmetics
  • Dermatologic Agents