The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels

Aging Male. 2020 Sep;23(3):173-178. doi: 10.1080/13685538.2018.1459544. Epub 2018 Apr 4.


Background: The aim of this study was to evaluate the relationship between mean platelet volume (MPV) and vitamin D levels according to ED severity.Methods: Between October 2015 and September 2017, patients who applied to the andrology outpatient clinic with an ED complaint were retrospectively reviewed. Patients with diabetes, hypertension, hyperlipidemia, malignancy, late-onset hypogonadism and smokers were not included in the study. The International Erectile Function Index-Erectile Function (IIEF-EF) questionnaire was used to assess the levels of erectile function. According to this scoring system, patients were divided into two groups. IIEF score: between 17 and 25 = mild ED (Group 1) and IIEF score between 16 and 0 = moderate-severe ED (Group 2). Blood samples of the patients were taken from antecubital vein and MPV and 25-hydroxyvitamin D [25(OH)D] levels were evaluated.Results: Ninety patients were included in the study (Group 1: n = 41, Group 2: n = 49). The mean age of the patients was 41.07 ± 8.56 and the mean body mass index (BMI) was 27.59 ± 3.91. 25(OH)D levels were found to be statistically lower in Group 2 (18.85 ± 6.09; 13.98 ± 7.10; p = .001). MPV levels were found to be statistically higher in Group 2 (10.05 ± 0.81; 10.78 ± 1.16; p = .001). Correlation between IIEF-EF scores and 25(OH)D levels was positive (p = .03, r = 0.22). There was negative correlation between IIEF-EF scores and MPV and between 25(OH)D levels and MPV levels [p = .003 for IIEF-EF/MPV, p = .04, r = -0.23 for 25(OH)D/MPV].Conclusion: There is a significant positive correlation between ED severity and 25(OH)D levels and there is a significant negative correlation between ED severity and MPV levels.

Keywords: 25-hydroxyvitamin D; Erectile dysfunction; endothelial dysfunction; inflammation; mean platelet volume.

MeSH terms

  • Adult
  • Biomarkers / blood
  • Erectile Dysfunction / blood*
  • Humans
  • Male
  • Mean Platelet Volume*
  • Middle Aged
  • Retrospective Studies
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood


  • Biomarkers
  • Vitamin D
  • 25-hydroxyvitamin D