Cu(II)/Ag(I)-Catalyzed Cascade Reaction of Sulfonylhydrazone with Anthranils: Synthesis of 2-Aryl-3-sulfonyl Substituted Quinoline Derivatives

Fei Wang; Pei Xu; Shun-Yi Wang; Shun-Jun Ji

doi:10.1021/acs.orglett.8b00525

Cu(II)/Ag(I)-Catalyzed Cascade Reaction of Sulfonylhydrazone with Anthranils: Synthesis of 2-Aryl-3-sulfonyl Substituted Quinoline Derivatives

Org Lett. 2018 Apr 20;20(8):2204-2207. doi: 10.1021/acs.orglett.8b00525. Epub 2018 Apr 4.

Authors

Fei Wang¹, Pei Xu¹, Shun-Yi Wang¹, Shun-Jun Ji¹

Affiliation

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology , Soochow University , Suzhou 215123 , China.

PMID: 29617145
DOI: 10.1021/acs.orglett.8b00525

Abstract

In this paper, a Cu(II)/Ag(I)-catalyzed cascade reaction of anthranils with sulfonylhydrazone to construct 2-phenyl-3-sulfonyl disubstituted quinoline derivatives under mild conditions was studied. The mechanism study indicated that this reaction involves radical addition, and new C-C, C-N, and C-S bonds were constructed in one step.

Publication types

Research Support, Non-U.S. Gov't