Protective Effects of Ellagitannin-Rich Strawberry Extracts on Biochemical and Metabolic Disturbances in Rats Fed a Diet High in Fructose

Nutrients. 2018 Apr 4;10(4):445. doi: 10.3390/nu10040445.


The present study compares the effects of two dietary strawberry extracts rich in monomeric (ME) or dimeric (DE) ellagitannins (ETs) on gastrointestinal, blood and tissue biomarkers in Wistar rats fed high-fructose diets. Both strawberry extracts beneficially affect the antioxidant status and lipid profile of the liver and serum. The ME extract shows a greater ability to inhibit lipid peroxidation in kidneys, more effectively decreases serum and liver triglycerides, and exerts greater anti-inflammatory effects in blood serum than the DE extract. The DE extract significantly reduces the activity of microbial enzymes in the cecum. These effects might be associated with higher cecum and urine levels of ET metabolites in rats fed with ME than in rats fed with DE. In conclusion, the diet-induced fructose-related disturbances observed in biochemical parameters are regulated by both extracts; nevertheless, the beneficial effects of the ME extract are mostly associated with systemic parameters, while those of the DE extracts are associated with local microbial activity.

Keywords: glutathione; inflammatory cytokines; microbiota activity; monomeric ellagitannins; nasutin A.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Biomarkers / blood
  • Cecum / drug effects*
  • Cecum / metabolism
  • Cecum / microbiology
  • Dietary Sugars / toxicity*
  • Fragaria* / chemistry
  • Fructose / administration & dosage
  • Fructose / toxicity*
  • Fruit
  • Gastrointestinal Microbiome / drug effects
  • Hydrolyzable Tannins / isolation & purification
  • Hydrolyzable Tannins / pharmacology*
  • Lipid Peroxidation / drug effects
  • Lipids / blood
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Oxidative Stress / drug effects
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Rats, Wistar


  • Anti-Inflammatory Agents
  • Antioxidants
  • Biomarkers
  • Dietary Sugars
  • Hydrolyzable Tannins
  • Lipids
  • Plant Extracts
  • ellagitannin
  • Fructose